Clinical Study "Common" Name (formal title)	Number of enrollees	Funding source (pharma/NIH)	Year complete	Primary publication	Full study treatment protocol
COPERNICUS (Controlled Phase 3 Evaluation of Repeated Intravitreal Administration of VEGF Trap-Eye in Central Retinal Vein Occlusion: Utility and Safety)	189	Regeneron	2013	Boyer D, Heier J, Brown DM, et al. Vascular endothelial growth factor Trap-Eye for macular edema secondary to central retinal vein occlusion: six-month results of the phase 3 COPERNICUS study [published correction appears in Ophthalmology. 2012 Nov;119(11):2204]. Ophthalmology. 2012;119(5):1024-1032. https://www.aaojournal.org/article/S0161-6420(12)00070-X/fulltext Brown DM, Heier JS, Clark WL, et al. Intravitreal aflibercept injection for macular edema secondary to central retinal vein occlusion: 1-year results from the phase 3 COPERNICUS study. Am J Ophthalmol. 2013;155(3):429-437.e7. https://www.ajo.com/article/S0002-9394(12)00682-4/fulltext